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KMID : 0882420120820020241
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Korean Journal of Medicine
2012 Volume.82 No. 2 p.241 ~ p.246
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A Case of Metformin-Induced Lactic Acidosis with Acute Kidney Injury Misdiagnosed as Hepatorenal Syndrome in a Cirrhosis Patient
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Kim Ok-Ki
Oak Chan-Young
Jeong Ji-Min
Lee Jeong-Won
Shin Min-Ho
Kim Nam-Ho
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Abstract
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Metformin is a well-established drug for the treatment of type 2 diabetes mellitus. The incidence of metformin-induced lactic acidosis is low, but the estimated mortality rate is approximately 50% in cases with lactic acidosis in combination with metformin therapy. Lactic acidosis occurs most often in patients with compromised cardiac, pulmonary, hepatic, and/or renal function. Acute kidney injury is a relatively frequent problem in cirrhosis patients. Hepatorenal syndrome is a diagnosis of exclusion, making its diagnosis difficult in the clinical field. We report a case of metformin-induced lactic acidosis with acute kidney injury that was misdiagnosed as hepatorenal syndrome in a cirrhosis patient.
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KEYWORD
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Metformin, Acidosis, Lactic, Liver Cirrhosis, Hepatorenal syndrome
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